Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Two cut-off points of eIS are reported with potential utility in clinical practice for detecting adults with T1DM with the highest CVD risk.Īltres ajuts: Financial support was provided through the Fondo de Investigación Sanitaria (FIS) PI09/01360 PI12/00954 and PI15/00567 as part of the National R+D+I Plan and was co-financed by the Instituto de Salud Carlos III-General Evaluation Branch (Spanish Ministry of Economy and Competitiveness) and the European Regional Development Fund (ERDF).Īquest document està subjecte a una llicència d'ús Creative Commons. Conclusions: eIS negatively correlates with the score of CVD risk in the ST1RE. min−1 sensitivity 65% and specificity 95%) with potential applicability in clinical practice.min−1 sensitivity 74% and specificity 76%) and high risk (8.Two cut-off points of eIS-EDC were identified for detecting moderate/high risk (8. The eIS-EDC equation had a significantly higher C-statistic both for moderate-/high-risk (p = 0. 778), respectively, for the eIS-CACTI equation. 913), respectively, for the eIS-EDC equation, and was 0. The C-statistic for predicting moderate/high risk and high risk was 0. Results: Both eIS-EDC and eIS-CACTI correlated negatively with ST1RE scores (eIS-EDC: r =−0. IR was assessed by the estimation of insulin sensitivity (eIS) using two validated prediction equations: the estimated insulin sensitivity developed from the Pittsburgh Epidemiology of Diabetes ComplicationsStudy(eIS-EDC)and the estimated insulin sensitivity developed from Coronary Artery Calcification in T1DM Study (eIS-CACTI) ST1RE was used to estimate 10-year CVD risk and to classify subjects into three groups according to their risk: low (<10% n = 105), moderate (10-20% n = 53), and high (≥20% n = 21). 1 years, duration of T1DM 16 (12-23) years) without established CVD were evaluated. Methods: A total of 179 adults with T1DM (50. Departament de Medicina) Data:īackground: We sought to assess the potential of insulin resistance (IR) for estimating cardiovascular disease (CVD) risk in adults with type 1 diabetes (T1DM) according to the scores of the Steno Type 1 Risk Engine (ST1RE). Departament d'Endocrinologia i Nutrició) Albert Fàbregas, Lara (Universitat Autònoma de Barcelona. Institut d'Investigació i Innovació Parc Taulí (I3PT)) Llauradó, Gemma (Universitat Autònoma de Barcelona. Institut de Recerca) Vendrell, Joan (Hospital Universitari Joan XXIII de Tarragona) González-Clemente, José-Miguel (Parc Taulí Hospital Universitari. Departament de Cirurgia) Martínez, Laia (Hospital Universitari Joan XXIII de Tarragona) Fernández-Veledo, Sonia (Hospital Universitari Joan XXIII de Tarragona) Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut d'Investigació i Innovació Parc Taulí (I3PT)) Astiarraga, Brenno (Hospital Universitari Joan XXIII de Tarragona) González-Sastre, Montserrat (Universitat Autònoma de Barcelona. Institut d'Investigació i Innovació Parc Taulí (I3PT)) Mazarico, Isabel (Parc Taulí Hospital Universitari. Utility of insulin resistance in estimating cardiovascular risk in subjects with type 1 diabetes according to the scores of the Steno Type 1 Cano, Albert (Parc Taulí Hospital Universitari.
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